This site usually comments on the different types of lipids but the comments on this post deals with what happens to to the body after an extreme weight loss.
This post will be an observation as to what can happen, when the body is breaking down fat and how the fat is eliminated.
Elimination of fat has to go through the blood stream before it is eliminated through body function. by doing so the body is coping with large amount of fats,that may clog the arteries, thereby penetrating the arteries in a manner that leads to the deposits of cholesterol and the body is so regulated that breaking down fat is done in a manner that the body can not cope with in a normal manner, this includes the fibrinolytic system, that eventually is overwhelmed by the end products of fats. Women are usually protected from early coronary disease through their menses but the ability for the body to eliminate fats after menses is not as readily avaiable, this is probably do to a lack of estrogen or other hormones.
As we age our cholesterol levels are harder to control.mainly due to aging.
Also, parts of the stomach are needed to complete many of the bodies regulatory systems and this includes many vitamins that are not available for synethsis through this weight lowering procedure.Not to say a women, not taking the necessary vitamins will have a tremendous hair loss. This reminds me of those that are genetically altered with the body not being able to manufacture cholesterol. These are those that are given certain vitamins that are needed for the manufacturing of a normal amount of apo B.
One should weigh all factors before embarking on such an EXTREME manner of weight loss. This also goes for weight loss done by traditional methods.
Stay well
Sunday, March 28, 2010
Monday, March 22, 2010
INFLAMATORY LIPIDS AND ASPIRIN INTOLERANCE
Studies done on subjects that were aspirin intolerant and those that were aspirin tolerant were found to have a high level of products generated from arachidonic acid, these mediators from the cyclooxygenase and lipoxygenase pathway showed conflicting resuts.
The study tested for the products leukotriene,prostaglandins, and 5-HPETE.
The study subjects were placed in two groups, group 1 aspirin tolerant were not found to have an increase in leuketrines, prostaglandins and 5-HPETE.
In group 2 the aspirin intolerant group found a significant elevations in Leuketrines,prostaglandin, and 5-HPETE.
The above study was done on subjects with a sinus condition, and to evaluate the mediators for there inflammatory effects on those with a sinus condition.
Also PAF was evaluated in both aspirin and aspirin intolerant subjects and found to have the same ratio in both groups.
PAF (Platelet Activating Factor is a strong proinflammatory lipid found in a variety of cell types (neutrophils, monocytes, endotheial cells and IGe sensitized basophils)and is a strong platelet aggregator.
PAF like lipid has been found in the blood of those and measured in those with cold urticaria (presenting with wheals or hives)and angiogenesis (this is the proliferation of new capillaries.
The above can fall into a condition all to itself or can be the result of Apolipoprotein H. In some diseases apo H acts as a cofactor or can work alone and exhibit an immune response whereby you have oxidized ldl cholesterol.
The above can also act as an injury to the endothial wall thereby promoting the ability of cholesterol to heal the vessel, thereby given credence to the claim that cholesterol is not a villian but merely acting as a wound healer.
Aspirin's role should be to stop inflammation but this is not the case with an intolerance to aspirin, the pathway between arachidonic acid and cyploxygenase should be inhibited by aspirin and the dose needed for inhibition is less than 81mgms, around 30 mgms is more intuned, and what is happening is the inflammatory lipids are able to produce rather than being blocked.
FYI there are foods that contain an aspirin base, they are mainly fruits all berries, tomatoes, peppers,peppermint wintergreen just to name the food groups. Salicylates are contained in plant material such as the willow bark
Atherosclerosis comes in many sizes and shapes. there is dietary cholesterol, genetic chlesterol(the apolipoproteins) and those generated by an immune response. All have to be addressed to keep the endothial cells in a viable manner.
PS Let me know how you like my new site format, I have google to thank for giving me the tools to set it up. I think its COOOL. Those cool googlegeist anyone in hematology can relate to a coultergeist both are similiar.
Stay Healthy
The study tested for the products leukotriene,prostaglandins, and 5-HPETE.
The study subjects were placed in two groups, group 1 aspirin tolerant were not found to have an increase in leuketrines, prostaglandins and 5-HPETE.
In group 2 the aspirin intolerant group found a significant elevations in Leuketrines,prostaglandin, and 5-HPETE.
The above study was done on subjects with a sinus condition, and to evaluate the mediators for there inflammatory effects on those with a sinus condition.
Also PAF was evaluated in both aspirin and aspirin intolerant subjects and found to have the same ratio in both groups.
PAF (Platelet Activating Factor is a strong proinflammatory lipid found in a variety of cell types (neutrophils, monocytes, endotheial cells and IGe sensitized basophils)and is a strong platelet aggregator.
PAF like lipid has been found in the blood of those and measured in those with cold urticaria (presenting with wheals or hives)and angiogenesis (this is the proliferation of new capillaries.
The above can fall into a condition all to itself or can be the result of Apolipoprotein H. In some diseases apo H acts as a cofactor or can work alone and exhibit an immune response whereby you have oxidized ldl cholesterol.
The above can also act as an injury to the endothial wall thereby promoting the ability of cholesterol to heal the vessel, thereby given credence to the claim that cholesterol is not a villian but merely acting as a wound healer.
Aspirin's role should be to stop inflammation but this is not the case with an intolerance to aspirin, the pathway between arachidonic acid and cyploxygenase should be inhibited by aspirin and the dose needed for inhibition is less than 81mgms, around 30 mgms is more intuned, and what is happening is the inflammatory lipids are able to produce rather than being blocked.
FYI there are foods that contain an aspirin base, they are mainly fruits all berries, tomatoes, peppers,peppermint wintergreen just to name the food groups. Salicylates are contained in plant material such as the willow bark
Atherosclerosis comes in many sizes and shapes. there is dietary cholesterol, genetic chlesterol(the apolipoproteins) and those generated by an immune response. All have to be addressed to keep the endothial cells in a viable manner.
PS Let me know how you like my new site format, I have google to thank for giving me the tools to set it up. I think its COOOL. Those cool googlegeist anyone in hematology can relate to a coultergeist both are similiar.
Stay Healthy
Monday, March 8, 2010
Broccoli Soup Low in Fat and Cholesterol
I had a huge bag of broccoli and went looking for a recipe for broccoli soup and I came upon a great site. lowfatcooking.about.com.
I made the soup and it was awesome. Thick creamy and flavorful. The recipe is as follows.
Cook time 30 min
Ingredients
2 tsp olive oil
half medium onion
1stalk of celery, finely chopped
1medium Yukon Gold Potato,peeled and chopped
4cups of fresh broccoli,including stems,chopped
2cups of low sodium,fat-freechicken or vegetable soup
one and one-half cups nonfat milk
Preparation
Heat oil in a soup pot or dutch oven. Gently saute onion and celery for 3 to 4 min, until onion is softened. Add potato chopped broccoli,followed by the broth and milk. Bring to a boil, then reduce heat,cover, and simmer for 20 min,until vegetables are tender.
Allow soup to cool slightly. At this point you can either use a cusinart mixing stick blending right in stock pot or place soup in a blender in two or three batches until smooth. I like the mixing stick everything is done in one pot. if using the blender after blending return mixture to pot and heat gently until ready to serve.
This soup is so light and airy you have to make it to appreciate that the ingredients used are not laden with creams or butters.
Per serving
88 cal
Cal from fat 16
Total fat 1.8gms
Sat Fat 0.3 g
Cholesterol 1mg
Sodium 83 mg
Carbohydrates 1.3g
Fiber3.1 g
Protein 4.9 g
Enjoy
Stay Healthy
I made the soup and it was awesome. Thick creamy and flavorful. The recipe is as follows.
Cook time 30 min
Ingredients
2 tsp olive oil
half medium onion
1stalk of celery, finely chopped
1medium Yukon Gold Potato,peeled and chopped
4cups of fresh broccoli,including stems,chopped
2cups of low sodium,fat-freechicken or vegetable soup
one and one-half cups nonfat milk
Preparation
Heat oil in a soup pot or dutch oven. Gently saute onion and celery for 3 to 4 min, until onion is softened. Add potato chopped broccoli,followed by the broth and milk. Bring to a boil, then reduce heat,cover, and simmer for 20 min,until vegetables are tender.
Allow soup to cool slightly. At this point you can either use a cusinart mixing stick blending right in stock pot or place soup in a blender in two or three batches until smooth. I like the mixing stick everything is done in one pot. if using the blender after blending return mixture to pot and heat gently until ready to serve.
This soup is so light and airy you have to make it to appreciate that the ingredients used are not laden with creams or butters.
Per serving
88 cal
Cal from fat 16
Total fat 1.8gms
Sat Fat 0.3 g
Cholesterol 1mg
Sodium 83 mg
Carbohydrates 1.3g
Fiber3.1 g
Protein 4.9 g
Enjoy
Stay Healthy
Saturday, March 6, 2010
TOO LITTLE CHOLESTEROL AND THE NEED FOR VITAMINS A K D E
Too little cholesterol increases the need for Vitamins A K D E.
Today statin users are being tested for a deficiencey in Vitamin D, this is because when cholesterol levels are low and kept low the need for this vitamin needs suplementation.
There is a disease condition called abetalipoproteinemia whereby the body has a defect, in that it is not able to manufacture or secrete lipoproteins containing products of the apolipoprotein B gene. This is due to a lack of a transfer protein which transports triglyceride, cholesterol ester and phospholipids from the surface of phospholipids.
In cholesterol that is too high apo B iS in abudance due to receptors that are malfunctioning and the body is not able to secrete Apo B and there is a build up of cholesterol on the walls of the arteries because of this defect.
High levels of apo B is considered a risk factor for coronary artery disease.
Vitamin E has come under scrutiny especially in smokers and the public has been advised not to take vit E because of the risk of developing lung cancer. So the case for vitamin E. Vit K fo those on a anticoagulant eg Heparin or Coumadin should check with your doctor as Vit K is the same as eating foods that contain Vit K and this will interfere with the medication.
Before taking any supplements check with your doctor first and make sure this is the right treatment for you as an individual.
It has been suggested that Vit E might stabilize or improve neuromuscular and retinial abnormalities seen in abetalipoproteinemia and manifestations of the disease such as neuropathy.Which many long term statin users develop.
Testing for Vit deficiences in those with high cholesterol and being treated either aggressively or passively with a statin is new and warrants investigation.
Stay Healthy
Today statin users are being tested for a deficiencey in Vitamin D, this is because when cholesterol levels are low and kept low the need for this vitamin needs suplementation.
There is a disease condition called abetalipoproteinemia whereby the body has a defect, in that it is not able to manufacture or secrete lipoproteins containing products of the apolipoprotein B gene. This is due to a lack of a transfer protein which transports triglyceride, cholesterol ester and phospholipids from the surface of phospholipids.
In cholesterol that is too high apo B iS in abudance due to receptors that are malfunctioning and the body is not able to secrete Apo B and there is a build up of cholesterol on the walls of the arteries because of this defect.
High levels of apo B is considered a risk factor for coronary artery disease.
Vitamin E has come under scrutiny especially in smokers and the public has been advised not to take vit E because of the risk of developing lung cancer. So the case for vitamin E. Vit K fo those on a anticoagulant eg Heparin or Coumadin should check with your doctor as Vit K is the same as eating foods that contain Vit K and this will interfere with the medication.
Before taking any supplements check with your doctor first and make sure this is the right treatment for you as an individual.
It has been suggested that Vit E might stabilize or improve neuromuscular and retinial abnormalities seen in abetalipoproteinemia and manifestations of the disease such as neuropathy.Which many long term statin users develop.
Testing for Vit deficiences in those with high cholesterol and being treated either aggressively or passively with a statin is new and warrants investigation.
Stay Healthy
Wednesday, March 3, 2010
PRESIDENT OBAMAS CHOLESTEROL LEVEL AND STRESS
It sems like everyone is blaming President Obamas increased cholesterol on what he eats. Apparently his cholesterol has risen from 176 prior to presidencey to 209 post election.
No one has addresed the stress factors that are related to his office. I'm sure every day he is bombarded with problems and with each new stress his cholesterol level rises.
He is up for more criticism now than probably at any other time in his life.
I hope he can find a good support group that will make feel more secure in his poition with the knowledge that he is doing a good job in spite of the Republicans.
my advice for what it is worth, take time to meditate and accent the positives and not the negatives.
I'm sure it is lonely at the top.
Stay Healthy
No one has addresed the stress factors that are related to his office. I'm sure every day he is bombarded with problems and with each new stress his cholesterol level rises.
He is up for more criticism now than probably at any other time in his life.
I hope he can find a good support group that will make feel more secure in his poition with the knowledge that he is doing a good job in spite of the Republicans.
my advice for what it is worth, take time to meditate and accent the positives and not the negatives.
I'm sure it is lonely at the top.
Stay Healthy
Tuesday, March 2, 2010
SAVING MONEY WITH CHOLESTEROL LOWERING STATINS
This post is for those who are switched to a new statin.
On my last visit to the doctor I went on a new statin. I wanted to try the statin first before I incurred a 3 month supply of the medication which would lead to wasted money and medication.
My new medication was Lipitor so I went on Lipitors web site and they had a free months trial of the medication. What I needed to do was ask for a separate medication request for one months supply from the doctor, this was in lieu of the usual three month prescription. I printed the free offer coupon from the web site. I took both the one month prescription and the free trial form to a local pharmacy and they filled the medication for free.
It is usually less expensive to deal with a carrier such as Medco, Medco is an on line pharmacy that fills prescriptions usually at a rate that is less expensive then neighborhood pharmacies and can be accessed through your prescription carrier, eg Medicare part D
Hopefully this information will save you some money. I would certainly look into this avenue when going on to a new medication. I have only tried it for the above statin.
Stay Healthy
On my last visit to the doctor I went on a new statin. I wanted to try the statin first before I incurred a 3 month supply of the medication which would lead to wasted money and medication.
My new medication was Lipitor so I went on Lipitors web site and they had a free months trial of the medication. What I needed to do was ask for a separate medication request for one months supply from the doctor, this was in lieu of the usual three month prescription. I printed the free offer coupon from the web site. I took both the one month prescription and the free trial form to a local pharmacy and they filled the medication for free.
It is usually less expensive to deal with a carrier such as Medco, Medco is an on line pharmacy that fills prescriptions usually at a rate that is less expensive then neighborhood pharmacies and can be accessed through your prescription carrier, eg Medicare part D
Hopefully this information will save you some money. I would certainly look into this avenue when going on to a new medication. I have only tried it for the above statin.
Stay Healthy
NOT ALL STATINS ARE EQUAL FOR LOWERING CHOLESTEROL
I recently had my quarterly visit with my lipid specialist and I'm now back on a statin. The statin Iam taking is not as strong as the one I took about a year ago. I am now taking Lipitor. I was on Crestor and Crestor is a much stronger statin then Lipitor. THe reason given to me by the pharmacy is Crestor lowers cholesterol much faster than the other statins.
I was on a combinatin of Crestor and Niaspan and the side effects I had from the combination have subsided on a scale from 1 to 10. Iam an 8.I still have some neuropathy and my bones do not creak as much as they did. Just a little. On the mend.
Usually some one in my age is not treated as aggressively(that 29 and holding group) but when asked if my calf hurt I had to say no it does not.
My vit D level was 20 and this was with taking the vitamin previous to the testing. I am taking 1000mg of Vit D and it seems to be working.
My ldl without the statin was high all other labs were normal.
I have to thank my doctors for putting up with me. I was not the ideal patient. I do not suffer in silence, something akin to the Princess and the Pea.
I have taken a statin on and off over the last 10 years with B12 and folic acid for a high Homocystine and when I had my heart cam done I was in the 20% group. This is good but there was a lot of material around the area.
The treatment I had and still continue is called Preventitive Cardiology and this is the name my group of doctor's go by and how they treat.
Treatment is geared to individual needs and how I was treated may not be the same as someone else.
I had to decide where I was going with my treatment and make the decision as to what I was going to take, along with my doctor's input.
I will continue to post on the mechanisms of lipids and report my progress .
Stay healthy
I was on a combinatin of Crestor and Niaspan and the side effects I had from the combination have subsided on a scale from 1 to 10. Iam an 8.I still have some neuropathy and my bones do not creak as much as they did. Just a little. On the mend.
Usually some one in my age is not treated as aggressively(that 29 and holding group) but when asked if my calf hurt I had to say no it does not.
My vit D level was 20 and this was with taking the vitamin previous to the testing. I am taking 1000mg of Vit D and it seems to be working.
My ldl without the statin was high all other labs were normal.
I have to thank my doctors for putting up with me. I was not the ideal patient. I do not suffer in silence, something akin to the Princess and the Pea.
I have taken a statin on and off over the last 10 years with B12 and folic acid for a high Homocystine and when I had my heart cam done I was in the 20% group. This is good but there was a lot of material around the area.
The treatment I had and still continue is called Preventitive Cardiology and this is the name my group of doctor's go by and how they treat.
Treatment is geared to individual needs and how I was treated may not be the same as someone else.
I had to decide where I was going with my treatment and make the decision as to what I was going to take, along with my doctor's input.
I will continue to post on the mechanisms of lipids and report my progress .
Stay healthy
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